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Dandona P, Karne R, Ghanim H, Hamouda W, Aljada A, Magsino Jr CH

These structures, while involved in disease progression, are not the root cause of neuronal degeneration and remain challenging to modulate without risking systemic side effects or impairing essential barrier functions

LetavayovaL.VlckovaV.BrozmanovaJ.2006Selenium: from cancer prevention to DNA damage

Brains were thawed for 5 min on an ice-cold dissection plate, dissected into 9 brain regions, individual brain areas flash frozen in liquid nitrogen, then stored at 80C as previously described

Their transition to a reactive state is characterized by profound metabolic alterations, marking a shift from a neuroprotective to a potentially neurotoxic profile